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Introduction to Biopharmaceutical Lyophilization and Spray Drying

Register for this course by selecting a date above.

Delivery methods

Course content

Why should you attend?

Lyophilization (freeze drying) and spray drying are used in biomanufacturing to remove solvent from drug products and improve stability. In this three-day hands-on course, you will learn the principles of biopharmaceutical drying process development and dried product analysis.  Specific concepts like heat and mass transfer, critical process parameters for cycle optimization, and the advantages/limitations of each technique will be presented.

Determination of critical product temperatures such as glass transition and collapse temperature are key to successful drying. Basics of process design through material characterization are demonstrated with laboratory sessions using differential scanning calorimetry and freeze dry microscopy.  Through hands-on labs and lectures, you will learn basic drying principles and how inputs such as temperature, formulation, time, and other factors influence final product quality attributes.  Gain experience in the operation of laboratory scale lyophilization (SP VirTis Genesis) and spray drying (Buchi B-290) equipment.

The course will also cover analytical techniques used to determine dried product quality.  Moisture content and water activity will be measured through techniques including hands-on labs for Karl Fischer titration, loss on drying, and TDLAS headspace analysis.  Examine dried product morphology and size using scanning electron microscopy and laser diffraction particle size analysis.   Additional analytical techniques covered include visual inspection, reconstitution, and powder rheology for density and cohesion strength.

Attend and you will learn

  • Basic principes of lyophilization and spray drying
  • To identify how changing drying process parameters affect the final dried product
  • To properly characterize critical material temperatures using differential scanning calorimetry and freeze-dry microscopy
  • To evaluate final product quality using multiple analytical techniques

Who should attend

Anyone looking for an introduction to biopharmaceutical drying technologies and dried product quality analysis. This course is suitable for a wide audience including those in manufacturing, process development, research, sales, marketing, or managerial roles.

Attend and you will receive

  • 20 hours of instruction
  • Notebook containing all course lecture and lab materials
  • Morning coffee and tea
  • Lunch
  • Certificate of completion

Instructor

Fee

$2,975

Location

All courses are offered on site at BTEC, other than online courses. The Golden LEAF BTEC building is located at 850 Oval Drive on NC State University's Centennial Campus.

If a course is full: Waitlist policy

If a course you want to take is already full, you are welcome to email mswoodya@ncsu.edu and ask to be placed on a waitlist for that course. The waitlist is used to fill any seats that become available when individuals registered for the course are unable to attend. If one or more seats become available, individuals on the waitlist are contacted in the order in which they were added to the list.

In addition to ensuring popular courses remain full, waitlists provide a means of tracking interest and determining if additional sessions are necessary. BTEC makes every effort to schedule additional course offerings if sufficient people are wait-listed. If a new offering is scheduled, those on the waitlist are notified before registration opens to the public.

Placement on a waitlist does not commit individuals to attending a course. It simply ensures that they are given first opportunity to enroll if a seat becomes available in a full course and that they are among the first to know if an additional course offering is scheduled during the current year.

BTEC is unable to provide information about the number of those wait-listed for any given course or an individual's place on such a list.

Payment

BTEC requires payment by credit card at the time of registration. BTEC accepts payment from all major credit cards including American Express, Visa, and MasterCard.

After registration, a payment receipt is automatically emailed. If you do not receive the email, please check your spam folders.

Any additional questions prior to registration should be directed to mswoodya@ncsu.edu.

Discounts available

A 20% discount is available for NIIMBL members for the following courses:

Check out BTEC’s professional development certificate program for an additional way to save money on short course costs. Any additional discount questions prior to registration should be directed to Serena Hodge, Industry Training Coordinator, at shodge@ncsu.edu.

Cancellation policies

Cancellation by registrant

To cancel a registration and be eligible for a refund of course fees, you must notify BTEC by email to mswoodya@ncsu.edu. Fees are refunded according to the following schedule:

  • 100% refund – If notification is received at least 15 business days in advance of course start date
  • 75% refund – If notification is received 10–14 business days in advance of course start date
  • 50% refund – If notification is received 6–9 business days in advance of course start date
  • No refund will be issued if notice is received 5 or fewer business days in advance of course start

Refunds will take 60–90 days for processing. Refunds requested more than 90 days after payment will be issued as a check.

Substitutions may be made up to two business days prior to the course start date. Notify the BTEC office by email to mswoodya@ncsu.edu. Please include the name and email contact for the replacement. Please note that BTEC is unable to honor substitutions for individuals taking discounted courses as part of the professional development certificate program.

Cancellation by BTEC

BTEC retains the right to cancel a professional development short course no less than 10 business days in advance of the scheduled course start date. Registrants will be notified by BTEC if a course is cancelled and will receive a full refund of registration fees paid. BTEC is not responsible for airfare penalties or other costs incurred due to cancellation.

Pre-course communication

Upon successful registration for a course, you will receive an automatically-generated email as well as another email from Melody Woodyard confirming your registration. If you do not receive these emails within two business days of registering for a course, please email mswoodya@ncsu.edu to confirm your registration.

Once registered, confirmed course participants will receive a series of emails approximately two weeks before the scheduled course with detailed information regarding travel to BTEC, parking information, and a short pre-course questionnaire.