Content

Applied Principles and Techniques of Depth Flow Filtration (DFF) and Tangential Flow Filtration (TFF) for BioPharm Purification

Delivery methods

Course content

upstream course

Upstream

downstream course

Downstream

This course can count toward your Professional Certificate in Biomanufacturing Science.

Why should you attend?

By participating in this comprehensive four-day filtration course, you will gain a solid understanding of the core principles and best practices for both depth filtration (DFF) and tangential flow filtration (TFF) as applied in modern biopharmaceutical upstream and downstream purification processes. This program is designed to equip you with practical skills and insights that can be directly implemented in your work environment in the areas of Process Development, Manufacturing, and Quality Assurance/Validation.

Attend and you will learn

The comprehensive lecture sections is expertly crafted to equip participants with a thorough understanding of the key parameters and factors influencing DFF and TFF membrane performance, as well as product recovery, for both upstream cell clarification and downstream UF/DF biopharmaceutical applications. The depth filtration (DFF) section explores the latest in polymeric membrane and matrix media technologies, while the tangential flow filtration (TFF) portion delves into both flat sheet cassette and hollow fiber element configurations, highlighting innovative advancements in the field.

Spanning the four immersive days, the hands-on laboratory workshop enables participants to conduct DFF and TFF application trials using cutting-edge benchtop systems. The curriculum dedicates two full days to cell clarification—first with DFF and then with TFF—followed by an in-depth focus on UF/DF by TFF on the third day. Data generated during these practical sessions will be thoroughly summarized, discussed, and applied to real-world scale-up challenges and SOP development. All workshop activities are grounded in the fundamental principles and techniques presented in the prerequisite lecture, ensuring a seamless integration of theory and practice.

What makes this filtration lecture and workshop different

  • Technology Focus and Not Sales/Marketing Focus — Unbiased and comprehensive lecture and workshop presenting the full spectrum of the acceptable technologies that no single vendor can offer. Both tubular (hollow fiber) and flat sheet membrane (cassette) formats are discussed and used in the workshop to provide comparable performance analysis.
  • Application Expertise — Depth and content of information presented and covered is unprecedented to other presentations. An interactive lecture that focuses on current issues and problems. The lecturer makes himself available to address each trainee’s current issues.
  • Applied Principles — Proven methods that lead to successful results and data interpretations from an instructor with over 40-years of application hands-on experience.
  • Diagnostic Tool — Membrane results are predictable—their performance is directly consistent to the principles and with any deviation in membrane performance—thus, analysis can be used to identify the process condition or design contributing to the cause.
  • Summary — How to design the appropriate setup, how to run the required procedures properly, what data to record, how to summarize the data, and how to interpret the data.

Who should attend

Engineers, scientists, managers, technical personnel, and researchers involved in biopharmaceutical filtration processes, with varying levels of knowledge.

Attend and you will receive

  • 29.75 hours of instruction
  • Notebook containing all course lecture and lab materials
  • Morning coffee and tea
  • Lunch
  • Afternoon beverage break
  • Certificate of completion

Instructor

John Rozembersky is the founder and president of Rozembersky Group Inc (RGI), an independent biofiltration consulting firm founded in 2005. 

With over 45 years of hands-on experience and in-depth knowledge in membrane and membrane bio-application technologies, and process systems, John is internationally recognized as a leading authority in Tangential Flow Filtration (TFF) in the biopharmaceutical sector from small scale bench-top development to large scale manufacturing process for both flat sheet membrane cassettes and hollow fiber membrane elements.

In the past decade, John has played a major lead role with teams that design, manufacture, implement and provide hands-on support and training to a full range of ultimate single-use TFF systems from bench scale to large scale manufacturing with solutions that resolve current major process and application pain points.

Fee

$3,995

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