Gain a deeper understanding of the fundamentals of recovery and purification operations for biopharmaceutical production and how these operations are designed for use at production scale. This course provides both theoretical and practical insight through lectures and laboratory activities.

June 29 – July 1, 2027

$3,100 registration fee

Register

Attend and you will learn 

• Theoretical and operational principles that underlie homogenization (and other cell lysis methods), centrifugation, chromatography, and tangential flow filtration—i.e., the downstream unit operations
• Regulatory expectations for design of downstream processing steps
• Experimental methods for determining process parameter ranges and material attributes (if applicable) for each unit operation
• Basic scale-up calculations and considerations for each operation
• How these unit operations come together to form an integrated process train for a variety of production scenarios, including intracellular products from E. coli, extracellular products from CHO, and inclusion body production

Who should attend

The course covers material that is especially relevant to scientists and engineers (BS, MS, PhD, or equivalent experience) working in downstream biopharmaceutical process development, particularly those new to the field. But the course’s overview of fundamental principles and design considerations for all of the operations associated with downstream processing make it worthwhile for others to consider, including the following:

• Manufacturing managers interested in knowing more about how the processes in their suites are designed
• Process Validation staff involved in defining operating ranges and attribute specifications
• Quality assurance professionals that support downstream processes
• Vendors who supply the biomanufacturing industry with downstream equipment and components

Instructors 

• Gary Gilleskie, Ph.D.
• Elissa Hudspeth