BTEC’s Bioprocess Services meet clients’ needs with a wide variety of state-of-the-art equipment and flexible facilities, including the following.

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Fermentation

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ABB 300 L BIOREACTOR

• ABB
• Agitation: max 400 rpm
• Temp: 150° C
• Pressure: 45 psi
• pH: 14.00
• pO₂: 200%
• Sparge: 450 slpm
• O₂: 150 slpm
• N₂: 90 slpm
• CO₂: 90 slpm
• Airflow overlay: 300 slpm
• Acid/Base/Antifoam/Level Pumps
• Impellers: 2
  • 14.5″ separation
  • 8.5″ from the bottom of the tank
  • 3 blades, 13″ in diameter, marine or rushton
• Tank height: 85 3/16″
• Tank diameter: 26″
• Shaft: 35.5″ long, 1.5″ diameter

SARTORIUS STEDIM 30 L BIOREACTOR

• Delta V
• Agitation: max 700 rpm
• Temp: 150° C
• Pressure: 45 psi
• pH: 14.00
• pO₂: 200%
• O₂: 45 slpm
• Acid/Base/Antifoam/Level Pumps

SARTORIUS STEDIM 30 L BIOREACTOR

• Sartorious DCU
• Agitation: max 700 rpm
• Temp: 150° C
• Pressure: 45 psi
• pH: 14.00
• pO₂: 200% 
• O₂: 45 slpm
• Acid/Base/Antifoam/Level Pumps
• Tank diameter: 12″
• Tank height: 28 5/8″
• Impellers: 2
  • 14.5″ separation
  • 8.5″ from the bottom of the tank
  • 3 blades—marine, 6″ in diameter, or 
    rushton, 13″ in diameter

SARTORIUS STEDIM 300 L BIOREACTOR

• Sartorious DCU
• Agitation: max 400 rpm
• Temp: 150° C
• Pressure: 45 psi
• pH: 14.00
• pO₂: 200%
• Sparge: 450 slpm
• O₂: 45 slpm
• Acid/Base/Antifoam/Level Pumps

Cell Culture

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SARTORIUS BIOSTAT CULTIBAG RM

• Up 20 L (10 L working volume)
• Agitation: 42 rocks/min
• Pressure: 50 mBar
• Temp: 40° C
• pO₂: to 250%

GE XCELLEREX XDR-50 SINGLE USE BIOREACTOR

• 5O L Volume
• Working volume min: 22 L cell culture, 25 L microbial
• Agitation: 100 rpm
• Condenser temp: 0–100° C
• CO₂: 0–100%
• DO₂: 0–200%
• MassFlow Controllers
• pH: 14.00
• Chiller for temp control

THERMOFISHER SCIENTIFIC HYCLONE 50 L WITH FINESSE CONTROL UNIT

• Single Use Bioreactor
• Agitation: 214 rpm
• Temp: 40° C
• pO₂: 100%
• 50 L working volume
• pH and DO measurement capabilities

THERMOFISHER SCIENTIFIC HYCLONE 50 L WITH SARTORIUS CONTROL UNIT

• Single Use Bioreactor
• Agitation: 214 rpm
• Temp: 40° C
• pO₂: 100%
• 50 L working volume
• pH and DO measurement capabilities

Downstream

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ALFA LAVAL LAPX404SGP-31 CENTRIFUGE

• Max speed: 9600 rpm
• Motor frequency: 60 Hz
• Max Density of Feed: 1100 kg/m³
• Max Density of sediment: 1400 kg/m³
• Max Density of Operation Liquid: 1000 kg/m³
• Process Temp Min/Max: 0-100 deg C

GE AKTAPROCESS CHROMATOGRAPHY SYSTEM

• Unicorn 5 Software
• 6 mm tubing path
• Flowrate: 4–180 L/hr
• Max Pressure: 6 Bar

GE AKTA AVANT 25 CHROMATOGRAPHY SYSTEM

• Unicorn Control System version 7
• Piston pump
• Metering flow rate (normal): 0.001–25 ml/min
• Flow rate: column packing 0.01–50 ml/min
• Pressure: 0 to 20 MPa (0–200 bar)
• Gradient Flow rate: 0.25–25 ml/min
• Quartenary: 1–25 ml/min
• Valves: 6 standard/6 optional
• Standard Valve Functions: Sample inlet, injection, Column, Outlet
• Pressure sensors: 4
• UV sensors: up to 2

GE AKTA AVANT 150 CHROMATOGRAPHY SYSTEM

• Unicorn Control System version 6/7
• Piston pump
• Metering flow rate (normal): 0.01–150 ml/min
• Flow rate column packing: 0.01–300 ml/min
• Pressure: 0 to 5 MPa (0–50 bar)
• Gradient Flow rate
• Binary: 1–150 ml/min
• Quartenary: 2–40 ml/min
• Valves: 6 standard/6 optional
• Standard Valve Functions: Sample inlet, injection, Column, Outlet
• Pressure sensors: 4
• UV sensors: up to 2

TECAN FREEDOM EVO DELIVERY SYSTEM

• Liquid Handling Arm
• Robotic Movement Arm
• Plate Reader
• Tshake
• Tvac
• Evo 100

GEA WESTFALIA WHISPERFUGE CENTRIFUGE

• Max. speed: 12,000 rpm
• Heavy Liquid: 1.0 kg/dm³
• Solids: 2.0 kg/m³

MILLIPORE BIOPHARM ENGINEERED SYSTEMS TFF

• 30 L vessel
• 5.2 – 28 L working volume
• Buffer exchange capababilies (UF/DF)

KROSFLO KR2I TFF

• Can process 1-10 L volumes
• Data collected electronically
• Automated process control
• Flow rates greater than 3 L/min