Introduction to Biopharmaceutical Lyophilization
Lyophilization (freeze drying) is used in biomanufacturing processes to remove solvent from drug products and improve stability. In this two-day hands-on course, you will learn the principles of biopharmaceutical lyophilization, process development, and dried product analysis.
In lectures and hands-on lab sessions, you will learn basic drying principles about how process inputs such as cycle temperature, time, formulation, and other factors influence final product quality attributes. Gain experience in the operation of laboratory scale lyophilization (SP VirTis Genesis) equipment. Using differential scanning calorimetry (DSC) and freeze dry microscopy (FDM), you will learn to determine critical product temperatures such as glass transition and collapse temperature which are key to designing a successful drying cycle. Moisture content and water activity of lyophilized products will be measured with Karl Fischer titration and tunable diode laser absorption spectroscopy (TDLAS) headspace analysis. Additional analytical techniques covered include visual inspection, reconstitution, and particulate analysis.
This course can be paired with Essentials of Spray Drying and Powder Analysis for a complimentary overview of additional drying techniques.
| Dates | Course | Cost | Registration |
|---|---|---|---|
| May 12-13, 2026 | Artificial Intelligence in FDA-Regulated Manufacturing: From Foundations to Implementation | $1,500 | Register |
| May 20–21, 2026 | Hands-On Essentials of Automation for Biomanufacturing | $2,050 | Register |
| May 27–29, 2026 | Preparative Chromatography Column Packing: Lab to Process Scale | $2,500 | Register |
| June 3–4, 2026 | Applied Cleaning Validation Practices: A STERIS Master Class | $2,000 | Register |
| June 9–10, 2026 | Introduction to Biopharmaceutical Lyophilization | $1,975 | Register |
| June 11, 2026 | Essentials of Spray Drying and Powder Analysis | $995 | Register |
| June 16–18, 2026 | Fundamentals of Mammalian Cell Line Development | $3,100 | Register |
| June 23–25, 2026 | Biopharmaceutical Assay Essentials | $3,100 | Register |
| June 23–25, 2026 | Fermentation Engineering | $3,100 | Register |
| June 30–July 2, 2026 | Hands-On Principles of mRNA Technology | $2,500 | Register |
| July 8–10, 2026 | Downstream Biopharmaceutical Processes: Fundamentals and Design | $3,100 | Register |
| July 14–16, 2026 | AAV Quality Attributes: Theory and Practice | $2,975 | Register |
| July 14–17, 2026 | Hands-On cGMP Biomanufacturing Operations | $4,200 | Register |
| July 28–31, 2026 | Hands-On Biomanufacturing of Vectors for Gene Therapy | $4,500 | Register |
| Aug 6, 2026 | Design of Experiments for Biomanufacturing | $500* | Register |
| Sept 29–Oct 1, 2026 | Cell Culture Engineering | $4,200 | Register |
| Oct 13–16, 2026 | Applied Principles and Techniques of Depth Flow Filtration (DFF) and Tangential Flow Filtration (TFF) for BioPharm Purification | $3,995 | Register |
| Nov 10–12, 2026 | PAT for Real-time Culture Monitoring and Closed-Loop Process Control | $2,975 | Register |
| November 12-19 | Microbial Contamination Control in Bioprocessing Operations | $2,975 |
Register by May 25
Attend and you will learn
- Basic principles of lyophilization
- To identify how drying process parameters affect the final dried product
- To properly characterize critical material temperatures using differential scanning calorimetry and freeze-dry microscopy
- To evaluate final product quality using multiple analytical techniques
Delivery methods
40% Lecture
60% Hands-on lab experience
Course content
14 hours of instruction
Who should attend
Anyone new to biopharmaceutical drying technologies and dried product quality analysis or with interest in advancing their understanding of the topic. This course is suitable for a wide audience including those in manufacturing, process development, research, sales, marketing, or managerial roles.